VH-replacement shapes the antibody repertoire by targeting non-pairing heavy-chains
Harry N White, Peter Chovanec, Laura Biggins, Elise C French, Georgia Bullen, Simon Andrews, Anne E. Corcoran
The paper investigates VH-replacement in B-cell development, finding it targets non-pairing productive VDJ rearrangements to reshape the antibody repertoire.
bioRxiv · Apr 7, 2025 · PreprintImmunology