Author

Laura Biggins

Babraham InstituteORCID 0000-0002-0975-1121Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Simon AndrewsiD· 2 shared Aled ParryiD· 1 shared Alex J. WhaleiD· 1 shared Anne E. CorcoraniD· 1 shared Elise C French· 1 shared Georgia Bullen· 1 shared Harry N WhiteiD· 1 shared Helen M.R. RobinsoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Simon AndrewsORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

TrAEL-seq captures DNA replication dynamics in mammalian cells

Neesha Kara, Laura Biggins, Vera V. Grinkevich, Alex J. Whale, Paola Garran-Garcia, Jhanavi Srinivasan, Peter J. Rugg‐Gunn, Simon Andrews, Aled Parry, Helen M.R. Robinson, Jonathan M. Houseley

TrAEL-seq is a method for profiling DNA replication dynamics in mammalian cells without requiring synchronization or drugs, showing replication fork speed and initiation zone effects.

bioRxiv · Jun 9, 2025 · PreprintMolecular Biology

VH-replacement shapes the antibody repertoire by targeting non-pairing heavy-chains

Harry N White, Peter Chovanec, Laura Biggins, Elise C French, Georgia Bullen, Simon Andrews, Anne E. Corcoran

The paper investigates VH-replacement in B-cell development, finding it targets non-pairing productive VDJ rearrangements to reshape the antibody repertoire.

bioRxiv · Apr 7, 2025 · PreprintImmunology