REGULATION OF HDL DYSFUNCTIONALITY BY PHOSPHATIDYLETHANOLAMINE LINKS POLY-UNSATURATED FATTY ACIDS WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASES
Malik Taradeh, Lise M. Hardy, Veronica D. Dahik, Marie Lhomme, Hua Wang, Canelle Reydellet, Clément Materne, Pukar KC, Eric Bun, Maud Clemessy, Jean-Paul Paı̈s de Barros, Sophie Galier, Éric Frisdal, Hervé Durand, Maharajah Ponnaiah, , Wilfried Le Goff
This study shows that arachidonic acid-containing phosphatidylethanolamine (ARA-PE) impairs HDL function, promoting atherosclerosis, while eicosapentaenoic acid-PE (EPA-PE) restores HDL function and may reduce ASCVD risk.
bioRxiv · May 27, 2025 · PreprintCell Biology