Complement Factor H (Y402H) polymorphism for age-related macular degeneration alters retinal lipids
Peng Shang, Johnson Hoang, Elise Hong, Zhaohui Geng, Helena Ambrosino, Eric Abnoosian, Xiaoyu Zhu, Min Ma, Nova A. Wei-Navarro, Beau R. Webber, Jun Qu, Sandra Rocio Montezuma, Martin‐Paul Agbaga, James R. Dutton, Deborah A. Ferrington
This study investigates how the CFH Y402H polymorphism and cigarette smoke extract affect lipid metabolism in iPSC-derived RPE cells, revealing genotype-dependent differences and CSE-induced lipid changes.
bioRxiv · Jan 7, 2026 · PreprintSystems Biology