Martin‐Paul Agbaga

DHA deficiency drives neural oxidized-lipid stress and microglial activation

This study shows that DHA deficiency causes lipid remodeling and microglial activation in mice, leading to oxidative stress and visual dysfunction, with APOE-dependent lipid disposal and galectin-3 involvement.

PEDF/PEDF-R Signaling Regulates Retinal Phospholipid Homeostasis and Photoreceptor Survival

This study shows that PEDF/PEDF-R signaling regulates retinal lipid homeostasis and photoreceptor survival through altered lipid metabolism and connectivity.

TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism

This study shows TMEM135 deficiency leads to a lipogenic state with increased monounsaturated fatty acids and DHA depletion, which is buffered by peroxisomal metabolism and can be reversed by fish oil.

Chronic Hypoxic Signalling Reprograms Metabolism and Alters Redox and Lipid Homeostasis in Rod Photoreceptors

This study investigates how chronic hypoxia reprograms metabolism and alters redox and lipid homeostasis in rod photoreceptors using a mouse model.

Complement Factor H (Y402H) polymorphism for age-related macular degeneration alters retinal lipids

This study investigates how the CFH Y402H polymorphism and cigarette smoke extract affect lipid metabolism in iPSC-derived RPE cells, revealing genotype-dependent differences and CSE-induced lipid changes.

Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver

This study shows that a Western diet in pregnant baboons alters the maternal microbiome and miRNA expression in placenta and fetal liver, potentially contributing to NAFLD and metabolic disease risk in offspring.