Jun Qu

Hex-MASP for Mapping the Whole-tissue Spatial Proteome and the Intra-brain Distribution of Monoclonal Antibodies

Hex-MASP enables high-resolution whole-tissue spatial proteomics mapping in mouse brains, revealing regional protein heterogeneity and antibody distribution.

Yck2 links mitochondrial function and pH homeostasis to cell wall remodeling and antifungal susceptibility in Cryptococcus neoformans

This study identifies Yck2's role in linking mitochondrial function, pH homeostasis, and cell wall remodeling in Cryptococcus neoformans, revealing mechanisms behind its impact on antifungal susceptibility.

L Fucose Dependent Biofilm Formation by Escherichia coli Enhances Polymicrobial Interactions and Antibiotic Tolerance on Urinary Catheters

This study shows that E. coli's L-fucose utilization pathway enhances biofilm formation and antibiotic tolerance in polymicrobial urinary catheter communities involving E. coli, P. mirabilis, and E. faecalis.

Complement Factor H (Y402H) polymorphism for age-related macular degeneration alters retinal lipids

This study investigates how the CFH Y402H polymorphism and cigarette smoke extract affect lipid metabolism in iPSC-derived RPE cells, revealing genotype-dependent differences and CSE-induced lipid changes.

Leveraging Dynamic Stability to Infer Regulation in Protein-Protein Interaction Networks: A Study of Infectious Vulnerability in COPD.

The paper infers regulatory relationships in protein-protein interaction networks from proteomic data to identify oxidative stress pathways linked to infectious vulnerability in COPD.

An Antibody Cocktail-Based Immunoaffinity-LC-MS Method Enabled Ultra-Sensitive and Robust Quantification of Circulating Proinsulin Proteoforms and C-peptide

This paper develops a sensitive LC-MS method to quantify circulating proinsulin proteoforms and C-peptide, showing improved separation of control and T1D groups compared to ELISA.

Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer

This study shows that ET-resistant breast cancer cells are more sensitive to ceramide-induced endoplasmic reticulum stress, mediated through TRAM1, leading to cell death.

Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination

This study shows that loss of Phb2 in Schwann cells disrupts myelination and dysregulates key transcription factors essential for peripheral nerve development.

Proteomics analysis reveals novel phosphorylated residues and associated proteins of the polyomavirus DNA replication initiation complex.

Dynamic Phosphorylation Regulates Eukaryotic Translation Initiation Factor 4A Activity During the Cell Cycle

This study identifies phosphorylation sites on eIF4A that regulate its activity during different cell cycle phases, showing how phosphorylation modulates translation and cell cycle progression.

Arginine methylation of Puf4 drives diverse protein functions

This study shows that arginine methylation of Puf4 regulates its functions in post-transcriptional gene regulation in Cryptococcus neoformans.

Proteomic network analysis of bronchoalveolar lavage fluid in ex-smokers to discover implicated protein targets and novel drug treatments for chronic obstructive pulmonary disease

The paper identifies differentially expressed proteins in COPD patients' bronchoalveolar lavage fluid and uses network analysis to find potential drug targets and repurposable therapies.

Rgs12 enhances osteoclastogenesis by suppressing Nrf2 activity and promoting the formation of reactive oxygen species

This study shows Rgs12 promotes osteoclastogenesis by inhibiting Nrf2 and increasing reactive oxygen species.