The impact of Mmu17 non-Hsa21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the "gold standard" revisited
Fayçal Guedj, Elise Kane, Lauren A. Bishop, Jeroen L. A. Pennings, Yann Hérault, Diana W. Bianchi
This paper compares the Ts65Dn and Ts66Yah mouse models of Down syndrome, showing that trisomy of non-orthologous Mmu17 genes worsens the phenotype and may explain failed human therapy translations.
bioRxiv · Sep 23, 2022 · PreprintNeuroscience