Fayçal Guedj

This study evaluates fasudil's effects on trisomy 21 neural progenitor cells, showing increased proliferation and reduced inflammation.

This paper compares the Ts65Dn and Ts66Yah mouse models of Down syndrome, showing that trisomy of non-orthologous Mmu17 genes worsens the phenotype and may explain failed human therapy translations.

Apigenin improved oxidative stress and behavior in Down syndrome models but had no significant birth defects.