Author

Jeroen L. A. Pennings

National Institute for Public Health and the EnvironmentORCID 0000-0002-9188-6358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Diana W. BianchiiD· 2 shared Fayçal GuedjiD· 2 shared Ashley Emily SiegeliD· 1 shared Elise Kane· 1 shared Fatimah Alsebaa· 1 shared Lauren A. Bishop· 1 shared Lauren J. MassinghamiD· 1 shared Ullrika SahliniD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Diana W. BianchiORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologyEnvironmental Toxicology and PharmacologyPeer-reviewedNov 30, 2024

Causal, Predictive or Observational? Different Understandings of Key Event Relationships for Adverse Outcome Pathways and Their Implications on Practice

Zheng Zhou, Jeroen L. A. Pennings, Ullrika Sahlin

This study examines the use of causal, observational, and predictive terms in Adverse Outcome Pathways (AOPs) and highlights discrepancies between terminology and practice in inferring causality.

4 citations

statistical modelbenchmark study

NeurosciencebioRxivPreprintSep 23, 2022

The impact of Mmu17 non-Hsa21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the "gold standard" revisited

Fayçal Guedj, Elise Kane, Lauren A. Bishop…·Diana W. Bianchi

This paper compares the Ts65Dn and Ts66Yah mouse models of Down syndrome, showing that trisomy of non-orthologous Mmu17 genes worsens the phenotype and may explain failed human therapy translations.

2 citations

mouseexperimental assay

GeneticsThe American Journal of Human GeneticsPeer-reviewedOct 23, 2020

Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model

Fayçal Guedj, Ashley Emily Siegel, Jeroen L. A. Pennings…·Diana W. Bianchi

Apigenin improved oxidative stress and behavior in Down syndrome models but had no significant birth defects.

32 citations

humanmouse