A microbiota-responsive polyfunctional cytotoxic CD4⁺ T-cell state promotes mucosal inflammation in ulcerative colitis
John P. Thomas, Sherine Hermangild Kottoor, Jonathan W. Lo, Tyler Wooldridge, Hajir Ibraheim, Jonathan L. Digby-Bell, Nathalie Lambie, Márton Ölbei, Balázs Bohár, Charlotte Wong, Eliyas Maroof, Yiwen Cao, Reema Baskar, Matthew Madgwick, Domenico Cozzetto, , Nick Powell
This paper identifies a microbiota-responsive polyfunctional cytotoxic CD4⁺ T-cell state linked to mucosal inflammation and treatment resistance in ulcerative colitis.
bioRxiv · Aug 17, 2026 · PreprintImmunology