Reema Baskar

A microbiota-responsive polyfunctional cytotoxic CD4⁺ T-cell state promotes mucosal inflammation in ulcerative colitis

This paper identifies a microbiota-responsive polyfunctional cytotoxic CD4⁺ T-cell state linked to mucosal inflammation and treatment resistance in ulcerative colitis.

IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell acute lymphoblastic leukemia

This study identifies IKAROS as a factor associated with antigen escape in B-ALL, showing that low IKAROS levels lead to reduced B-cell antigen expression and resistance to CD19- and CD22-targeted therapies.

Supervised dimensionality reduction for exploration of single-cell data by Hybrid Subset Selection - Linear Discriminant Analysis

This paper introduces a supervised dimensionality reduction method using hybrid subset selection with linear discriminant analysis to improve visualization and analysis of single-cell data.

Integrating transcription factor abundance with chromatin accessibility in human erythroid lineage commitment

The paper introduces InTAC-seq to quantify chromatin accessibility and transcription factor abundance in fixed cells, showing GATA1's role in erythroid lineage commitment.