Excitatory amino acid transporter 1 supports adult hippocampal neural stem cell self-renewal.
Joshua D. Rieskamp, Ileanexis Rosado-Burgos, Jacob E. Christofi, Eliza Ansar, Dalia Einstein, Ashley E. Walters, Valentina Valentini, John P. Bruno, Elizabeth D. Kirby
The paper shows that EAAT1 facilitates glutamate-induced self-renewal of adult hippocampal NSCs through lipogenesis, highlighting a non-canonical mechanism of niche sensing.
iScience · Jan 1, 2022Peer-reviewedNeuroscience