Joshua D. Rieskamp

Neural stem and progenitor cells support and protect adult hippocampal function via vascular endothelial growth factor secretion.

This study shows that adult hippocampal NSPCs secrete VEGF, which supports and protects hippocampal function independently of neurogenesis.

Excitatory amino acid transporter 1 supports adult hippocampal neural stem cell self-renewal.

The paper shows that EAAT1 facilitates glutamate-induced self-renewal of adult hippocampal NSCs through lipogenesis, highlighting a non-canonical mechanism of niche sensing.

Neural stem cell expressed vascular endothelial growth factor maintains the neurogenic vascular niche of the adult mouse hippocampus

This study shows that neural stem cells in the adult mouse hippocampus use VEGF to maintain their connection to vasculature and regulate their own motility and quiescence through internal signaling.

Stereological characterization of neurogenic niche secretory cell types in the mouse dorsal dentate gyrus

The paper estimates cell density of neurogenesis-modulating secretory cell types in the dorsal dentate gyrus of adult mice using stereological methods and immunohistochemical markers.

Defining the adult hippocampal neural stem cell secretome: in vivo versus in vitro transcriptomic differences and their correlation to secreted protein levels

The paper compares in vitro and in vivo transcriptomic and proteomic profiles of adult hippocampal NSPCs, finding discrepancies in secreted protein abundance and gene expression.