Elizabeth D. Kirby

The paper quantifies vascular features of the dentate gyrus using 3D imaging, revealing both known and novel aspects of vessel morphology in adult mice.

This study shows that the vascular niche in the dentate gyrus of mice refines postnatally, with NSPCs moving closer to blood vessels and proliferating cells compressing symmetrically.

This study shows that adult hippocampal NSPCs secrete VEGF, which supports and protects hippocampal function independently of neurogenesis.

This study compares the efficiency and effects of tamoxifen injection versus chow administration in inducing recombination and altering adult hippocampal neurogenesis in mice.

This study compares bulk and single-cell RNAseq for identifying differentially expressed genes in adult hippocampal NSCs, finding single-cell methods miss high-fold-change genes but can be optimized for in vivo use.

The paper shows that EAAT1 facilitates glutamate-induced self-renewal of adult hippocampal NSCs through lipogenesis, highlighting a non-canonical mechanism of niche sensing.

This study shows that neural stem cells in the adult mouse hippocampus use VEGF to maintain their connection to vasculature and regulate their own motility and quiescence through internal signaling.

The paper estimates cell density of neurogenesis-modulating secretory cell types in the dorsal dentate gyrus of adult mice using stereological methods and immunohistochemical markers.

The paper shows that recombination of one floxed gene does not reliably predict recombination of another floxed gene in single neural stem cells, suggesting potential for false conclusions in cell autonomous studies.

The paper compares in vitro and in vivo transcriptomic and proteomic profiles of adult hippocampal NSPCs, finding discrepancies in secreted protein abundance and gene expression.