Chronic but not acute morphine exposure reversibly impairs spike generation and repetitive firing in a functionally distinct subpopulation of orexin neurons
Elizabeth A. Berry, Ellen N. Huhulea, Masaru Ishibashi, Ronald McGregor, Jerome M. Siegel, Christopher S. Leonard
This study shows chronic morphine exposure impairs spike generation in a specific subpopulation of orexin neurons, while sparing others, and this effect is reversible.
bioRxiv · Mar 20, 2025 · PreprintNeuroscience