Author

Jerome M. Siegel

United States Department of Veterans AffairsORCID 0000-0003-2898-0111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:rat· 1

Frequent Co-Authors

Ming‐Fung Wu· 2 shared Ronald McGregoriD· 2 shared Thomas C. ThannickaliD· 2 shared Christopher S. LeonardiD· 1 shared Elizabeth A. Berry· 1 shared Ellen N. HuhuleaiD· 1 shared Marcia E. Cornford· 1 shared Masaru IshibashiiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 15 mutual co-author links

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2 shared papersNeuroscience

Ming‐Fung Wu

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 12, 2025

Brainstem pathology in human narcolepsy: Neurodegeneration in the locus coeruleus in narcoleptic humans, but not in genetically narcoleptic mice or dogs

Thomas C. Thannickal, Ming‐Fung Wu, Marcia E. Cornford, Jerome M. Siegel

DOI 10.1101/2025.04.12.648456

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 20, 2025

Chronic but not acute morphine exposure reversibly impairs spike generation and repetitive firing in a functionally distinct subpopulation of orexin neurons

Elizabeth A. Berry, Ellen N. Huhulea, Masaru Ishibashi…·Christopher S. Leonard

This study shows chronic morphine exposure impairs spike generation in a specific subpopulation of orexin neurons, while sparing others, and this effect is reversible.

DOI 10.1101/2025.03.20.644444

mouseelectronic health records

𝕏 PostBluesky

NeurosciencebioRxivPreprintSep 22, 2023

Opiate anticipation,opiate induced anatomical changes in hypocretin (Hcrt, orexin) neurons and opiate induced microglial activation are blocked by the dual Hcrt receptor antagonist suvorexant, while opiate analgesia is maintained

Ronald McGregor, Ming‐Fung Wu, Thomas C. Thannickal, Jerome M. Siegel

This study shows that suvorexant blocks morphine-induced changes in Hcrt neurons, microglial activation, and anticipatory behavior but preserves morphine analgesia.

7 citations

humanexperimental assay

𝕏 PostBluesky