Pharmacology & ToxicologybioRxivPreprint
A Prodrug Strategy to Reposition Atovaquone as a Long-Acting Injectable for Malaria Chemoprotection
Anil K. Sen Gupta, Anders M. Eliasen, Wil Andahazy…·Arnab K. Chatterjee
This paper develops three prodrug formulations of atovaquone for long-acting injectable malaria chemoprotection, showing two maintain therapeutic plasma levels for over 70 and 30 days in monkeys.