Author

Fei Zhou

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Organism:zebrafish· 1

Frequent Co-Authors

Rick K HuangiD· 3 shared Abraham J. MortoniD· 2 shared Andrés FinziiD· 2 shared Doreen MatthiesiD· 2 shared Halima Medjahed· 2 shared Marzena PazgieriD· 2 shared Suneetha Gottumukkala· 2 shared William David TolbertiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Rick K HuangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional Implications of the Conformational Landscape of a Multidrug Transporter Revealed by Structures of Zebrafish Abcb4

Jingyu Zhan, Chao-Ming Hsieh, Lothar Esser, Zabrina C. Lang, Abraham J. Morton, Robert W. Robey, Fei Zhou, Suresh V. Ambudkar, Rick K Huang, M GOTTESMAN, Di Xia

This study reveals the conformational dynamics of zebrafish Abcb4 using cryo-EM, showing its open-and-close motion and substrate-binding flexibility, which may explain its polyspecificity.

Nature Communications · May 30, 2026Peer-reviewedBiochemistry

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

Jonathan Richard, Michael W. Grunst, Ling Niu, Marco Aurelio Díaz-Salinas, Li Zhu, William David Tolbert, Lorie Marchitto, Fei Zhou, Catherine Bourassa, H.O. Kim, Sri Lakshmi Tejaswi Boodapati, Derek Yang, Ta-Jung Chiu, Hung-Ching Chen, Mehdi Benlarbi, , Andrés Finzi

This study shows that the CD4 mimetic CJF-III-288 enables anti-CoRBS antibodies to mediate ADCC by stabilizing an asymmetric open Env conformation.

Nature Communications · Dec 1, 2025Peer-reviewedMicrobiology

Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir

Jérémie Prévost, Yaozong Chen, Fei Zhou, William David Tolbert, Romain Gasser, Halima Medjahed, Manon Nayrac, Dung Ngoc Pham Nguyen, Suneetha Gottumukkala, Ann Jones Hessell, Venigalla Basaveswara Rao, Edwin V. Pozharski, Rick K Huang, Doreen Matthies, Andrés Finzi, Marzena Pazgier

This study identifies multiple molecular determinants of HIV-1 CRF01_AE resistance to temsavir, showing that resistance involves crosstalk between His375 and inner domain layers.

Nature Communications · Oct 23, 2023Peer-reviewedMolecular Biology