The BRCA1 isoform, BRCA1-IRIS, operates independently of the full-length BRCA1 in the Fanconi anemia pathway
Andrew G. Li, Brenda C. Chan, Elizabeth C. Murphy, Ye He, Muhammed Ors, Qing Kong, Sharon B. Cantor, Joan S. Brugge, Myles A Brown, David M. Livingston
This study identifies BRCA1-IRIS as a critical isoform for ICL repair, distinct from BRCA1-p220, by interacting with FANCD2 and promoting its ubiquitylation.
bioRxiv · Nov 2, 2022 · PreprintMolecular Biology