Author

Brenda C. Chan

Dana-Farber Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew G. Li· 1 shared Anthony G. LetaiiD· 1 shared Antonio J. AlmazaniD· 1 shared Cheyanne Walker-WilliamsiD· 1 shared Cloud Peter PaweletziD· 1 shared Cole J. Turner· 1 shared Daryl GriffiniD· 1 shared David Allen BarbieiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Andrew G. Li

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Author profile →

2 papers

Recent·Most cited

Drug tolerant persisters and immunotherapy persister cells exhibit cross-resistance and share common survival mechanisms

Maria Davern, Cole J. Turner, Daryl Griffin, Lara Bencsics, Brenda C. Chan, Jasmine Yun-Tong Kung, Michael Olson, Cheyanne Walker-Williams, Shaili Soni, Leah Krotee, Michael Yorsz, Gabriella Antonellis, Patrick Hall Lizotte, Cloud Peter Paweletz, Jeremy A. Ryan, , Anthony G. Letai

This study identifies common survival mechanisms between drug-tolerant persisters and immunotherapy persisters, showing they share reduced mitochondrial apoptotic sensitivity and cross-resistance to therapies.

Cell Death and Differentiation · Dec 26, 2025Peer-reviewedCancer Biology

The BRCA1 isoform, BRCA1-IRIS, operates independently of the full-length BRCA1 in the Fanconi anemia pathway

Andrew G. Li, Brenda C. Chan, Elizabeth C. Murphy, Ye He, Muhammed Ors, Qing Kong, Sharon B. Cantor, Joan S. Brugge, Myles A Brown, David M. Livingston

This study identifies BRCA1-IRIS as a critical isoform for ICL repair, distinct from BRCA1-p220, by interacting with FANCD2 and promoting its ubiquitylation.

bioRxiv · Nov 2, 2022 · PreprintMolecular Biology