Human Cerebral Spheroids Undergo Activity Dependent Changes In Cellular Composition And MicroRNA Expression
Thomas Parmentier, Fiona James, Elizabeth Hewitson, Craig D. C. Bailey, Nicholas Werry, Steven D. Sheridan, Roy H. Perlis, Melissa L. Perreault, Luís Gaitero, Jasmin Lalonde, Jonathan LaMarre
The paper shows that increasing neuronal activity in human cerebral spheroids increases new neurons and decreases new glial cells, with reduced miR-135a expression.
Scientific Reports · Jun 1, 2022Peer-reviewedNeuroscience