The metabolic reprogramming of T cells controls airway remodeling in severe asthma
Hope Steele, Elizabeth Kato, Garrison Dell, Maeve Fink, Andrew Ghastine, Ashley Willicut, Hilde Cheroutre, Mitchell Kronenberg, Rana Herro
This study identifies OXPHOS and LIGHT as key drivers of Th17 cell metabolism and airway remodeling in MGA, showing their dual blockade can reverse disease features.
bioRxiv · Mar 22, 2026 · PreprintImmunology