Rat Hindlimb Amputation Model Shows Analgesia and Sexually Dimorphic Cold Hypersensitivity with Immediate Targeted Muscle Reinnervation
José M. Zepeda, Gabriella Mraz, Elizabeth Roth, Dorothée Weihrauch, Gwendolyn M. Hoben
This study uses a rat hindlimb amputation model to show that immediate targeted muscle reinnervation reduces pain behaviors and prevents neuroma formation, with sex-specific effects on cold hypersensitivity.
Journal of Pain · Jun 12, 2025Peer-reviewedAnimal Behavior & Cognition