Seo Yeon Yoon

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.

The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.

The paper investigates the role of microglia in APOE4-driven Alzheimer's pathology using a chimeric model, finding that microglia are required for APOE4-induced pathologies.

The paper examines brain hemodynamic responses and structural differences in extremely preterm and full-term individuals solving fraction subtraction using different strategies.

This study identifies early and persistent effects of APOE4 on neuronal gene expression networks in aging, suggesting the need for early interventions in Alzheimer's disease.

The paper shows that PV+ and SST+ interneurons in the DG and CA3 differentially modulate information flow to CA1 by altering coupling signatures from CA3 and entorhinal cortex.

Aβ1-42 induces brain hypometabolism, network hyperactivity, and behavioral changes via NOX2-mediated oxidative stress, suggesting a novel therapeutic target for Alzheimer's disease treatment.

The paper shows that reduced hippocampal sharp-wave ripple abundance and associated slow gamma power in Alzheimer’s disease mouse models predict later spatial memory impairments.