Clonal evolution of hematopoietic stem cells after cancer chemotherapy
Hidetaka Uryu, Koichi Saeki, Hiroshi Haeno, Chiraag Deepak Kapadia, Ken Furudate, Jyoti Nangalia, Michael Spencer Chapman, Linda Zhang, Jennifer Padilla, Li Zhao, Joanne I. Hsu, Chong Zhao, Shujuan Chen, Tomoyuki N. Tanaka, Zongrui Li, , Koichi Takahashi
This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.
Nature Genetics · Jul 1, 2025Peer-reviewedCancer Biology