Author

Joanne I. Hsu

Baylor College of MedicineORCID 0000-0002-1194-0650Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:clustering· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Jyoti NangaliaiD· 2 shared Koichi TakahashiiD· 2 shared Margaret A. GoodelliD· 2 shared Michael Spencer ChapmaniD· 2 shared Aditi VediiD· 1 shared Alex CaganiD· 1 shared Anna Clay· 1 shared Anna SantarsieriiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Jyoti NangaliaORCID

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2 papers

Recent·Most cited

The long-term effects of chemotherapy on normal blood cells

Emily Mitchell, My H. Pham, Anna Clay, Rashesh Sanghvi, Nicholas Williams, Sandra Pietsch, Joanne I. Hsu, Nina Friesgaard Øbro, Hyunchul Jung, Aditi Vedi, Sarah Moody, Jingwei Wang, Daniel A. Leongamornlert, Michael Spencer Chapman, Ellie Dunstone, , Michael R. Stratton

This study examines the long-term effects of chemotherapy on normal blood cells by analyzing mutation burdens and cell population structure in treated individuals.

Nature Genetics · Jul 1, 2025Peer-reviewedCell Biology

Clonal evolution of hematopoietic stem cells after cancer chemotherapy

Hidetaka Uryu, Koichi Saeki, Hiroshi Haeno, Chiraag Deepak Kapadia, Ken Furudate, Jyoti Nangalia, Michael Spencer Chapman, Linda Zhang, Jennifer Padilla, Li Zhao, Joanne I. Hsu, Chong Zhao, Shujuan Chen, Tomoyuki N. Tanaka, Zongrui Li, , Koichi Takahashi

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

Nature Genetics · Jul 1, 2025Peer-reviewedCancer Biology