Hiroshi Haeno

The paper identifies cycling persisters (CPs) in cancer organoids and shows that elevated NR2F1-mediated cholesterol biosynthesis contributes to chemotherapy resistance.

geneSCOPE identifies spatial gene modules and cell-cell interactions by integrating ecology-inspired statistics and network analysis in spatial transcriptomics data.

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.