Single-vessel transcriptome map pathological landscapes and reveal NR2F2-mediated smooth muscle cell phenotype acquisition in capillary malformations
Vi Nguyen, Irving Mao, Siyi He, Ivonne Astrid Arias Castellanos, Mackenzie Azuero, Marcelo L. Hochman, Rong H. Yin, Laena Pernomian, Elliott H Chen, Harold Ira Friedman, Yanhua Chen, Qun Lu, Daping Fan, Camilla Ferreira Wenceslau, Dong‐bao Chen, , Wenbin Tan
The paper constructs a spatial transcriptomic atlas of capillary malformations, identifies EndMT and AJ disruption, and shows NR2F2 drives SMC phenotype acquisition in vascular lesions.
bioRxiv · Sep 2, 2025 · PreprintPathology