Daping Fan

NicheCorr identifies niche-specific gene co-expression changes in spatial transcriptomics data, revealing spatially structured signaling interactions in liver and pancreatic cancer datasets.

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

The paper constructs a spatial transcriptomic atlas of capillary malformations, identifies EndMT and AJ disruption, and shows NR2F2 drives SMC phenotype acquisition in vascular lesions.

This study shows that Alistipes timonensis colonization in Il10-deficient mice delays colitis by altering the host lipidome and delivering anti-inflammatory outer membrane vesicles containing immunomodulatory lipids.

This paper discovers a new class of cancer immunogenic chemotherapeutic leads called aspercyclicins through a high-throughput screening platform and structural elucidation techniques.