A Single-Short Partial Reprogramming of the Endothelial Cells decreases Blood Pressure via attenuation of EndMT in Hypertensive Mice
Laena Pernomian, Emily W. Waigi, Vi Nguyen, Ahmed Dawood Mohammed, Tiago Januario Da Costa, Milene Tavares Fontes, Jason Lee Kubinak, Andrew Vieira Aitken, Vinicia Campana Biancardi, Kamryn Gleason, Tarek M. Shazly, David A. Sinclair, Cameron Grant McCarthy, Yunguan Wang, Wenbin Tan, Camilla Ferreira Wenceslau
This study shows that reprogramming endothelial cells in hypertensive mice with OSK factors reduces blood pressure by inhibiting EndMT and vascular damage.
Circulation Research · Sep 3, 2025Peer-reviewedPhysiology