Vgll2 and Tead1 Govern Generation of Mouse and Human Hypothalamic Hypocretin (Orexin) Neurons
Ruofan Wei, Amirhossein Sheikhshahrokh, Elnaz Saeidi, Cecilia Liliana Gomez Inclan, Aswathi Gopalakrishnan, Brad Balderson, Mikael Bodén A, Michael Piper, Stefan Thor
This paper identifies Vgll2 and Tead1 as key regulators of Hcrt neuron generation in mouse and human, showing their role in differentiation and potential for cell therapy.
bioRxiv · Apr 1, 2026 · PreprintNeuroscience