Michael Piper

The paper identifies systematic regional bias in ChIP-seq data across multiple experiments and proposes metrics to improve data integration.

This paper identifies Vgll2 and Tead1 as key regulators of Hcrt neuron generation in mouse and human, showing their role in differentiation and potential for cell therapy.

This study identifies Sox9 and Nfi transcription factors as regulators of G0 entry and ependymal maturation in midbrain dopamine progenitors, with effects dependent on developmental timing.

This study investigates the role of PRC2 in mouse cortical development, finding that homozygous mutations lead to structural and neuronal dysregulation, while heterozygous mutations show distinct effects.

Cytocipher identifies significant cell populations in scRNA-seq data by statistically determining transcriptionally distinct clusters, revealing new cell types and subpopulations across various biological contexts.

This study shows that while most hypothalamic neurons develop normally without the H3K27me3 epigenetic mark, specific neuronal subtypes are sensitive to its loss.

ChIP-R improves the reproducibility of ChIP-seq and ATAC-seq peak calls by statistically combining replicates, outperforming existing methods in recovering transcription factor binding sites.