Discovery and chemical biology of CDK8 inhibitors reveals insights for kinase inhibitor development.
Franck Borel, Y.V. Le Bihan, Béatrice Josselin, Thomas Robert, Julien Duez, Lucie Angevin, Elisabeth Simboeck, Susana Prieto, Elsie Hodimont, Jean-Luc Ferrer, Liliana Krasińska, Sandrine Ruchaud, Daniel Fisher
The paper identifies CDK8/19 inhibitors with reduced off-target toxicity and shows that their loss is not cytotoxic but reduces cell proliferation.
bioRxiv · Nov 6, 2025 · PreprintBiochemistry