Cigarette smoke sets up a pro-inflammatory circuit in the lung that induces the hyper-activation of autoreactive T helper cells
Nuria Álvarez‐Sánchez, Annette Haughian, Brendan Cordeiro, Deeva Uthayakumar, Elvira Paneda, Thomas A Heaney, Molly Pitkethly, Jhenifer Gabriela Vasquez Rojas, Emily Pullen, Elyse Latreille, Chao Wang, Warren L. Lee, Martin Stampfli, Clinton S. Robbins, Shannon E. Dunn
This study shows that cigarette smoke exposure promotes a pro-inflammatory lung environment that enhances the activation of myelin-reactive T helper cells, contributing to autoimmune disease.
bioRxiv · Aug 6, 2025 · PreprintImmunology