5'-triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling
Jacek Szymański, Magdalena Wołczyk, Ivan Trus, Zara Naz, Nathalie Idlin, Justyna Jackiewicz, Elzbieta Nowak, Christine Wuebben, Gunther Hartmann, Juri Rappsilber, Gracjan Michlewski
The paper shows that 5'-pppG RNAs are less immunogenic than 5'-pppA RNAs due to interactions with GTP-binding proteins, which may help viruses and Pol III transcripts evade innate immune detection.
bioRxiv · Dec 22, 2023 · PreprintMolecular Biology