Gracjan Michlewski

5'-triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling

The paper shows that 5'-pppG RNAs are less immunogenic than 5'-pppA RNAs due to interactions with GTP-binding proteins, which may help viruses and Pol III transcripts evade innate immune detection.

TRIM25 inhibits Influenza A infection by destabilising its mRNA and is redundant for the RIG-I pathway.

This study shows TRIM25 inhibits Influenza A virus by destabilizing its mRNA and is not required for the RIG-I pathway.

RNA pull-down-Confocal Nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases α-Synuclein levels

The paper introduces RP-CONA, a method to identify RNA-protein interaction modulators, and finds quercetin inhibits HuR-pri-miR-7-1 interaction, increasing miR-7 and reducing α-Synuclein.

Structural basis for terminal loop recognition and processing of pri-miRNA-18a by hnRNP A1

This study reveals how hnRNP A1 binds to the terminal loop of pri-mir-18a, destabilizing stem base-pairing to enhance miRNA processing.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

This study identifies the PRY/SPRY domain of TRIM25 as its RNA-binding region and shows its role in ubiquitination.