Cancer BiologybioRxivPreprint
Rho-mediated gene transcription promotes BRAF inhibitor resistance in de-differentiated melanoma cells
SA Misek, KM Appleton, TS Dexheimer…·RR Neubig
This study identifies RhoA-mediated gene transcription as a mechanism of BRAF inhibitor resistance in melanoma, showing that targeting this pathway can re-sensitize resistant cells to vemurafenib.
DOI 10.1101/381806