GWAS of Extended Prescription Analgesic Use Identifies Novel Genetic Loci in Chronic Pain
Charli E Harlow, Emeka Uzochukwu, Hazel A Fernando, Charles E. Mordaunt, Jordan M. Hughey, John D. Eicher, Lara Robinson, Nicholas Bowker, Laurence J Howe, Jimmy Liu, Adrián Cortés, Paul Wilson, Usha Gungabissoon, Victoria S. Benson, Anthony Nash, , M. Zameel Cader
This study uses prescription analgesic use data to identify 140 genetic associations with chronic pain, including 78 novel loci, and suggests new biological mechanisms.
Nature Communications · May 28, 2026Peer-reviewedGenetic & Genomic Medicine