M. Zameel Cader

A highly efficient method to differentiate CGRP-expressing peptidergic nociceptors from human induced pluripotent stem cells

This paper describes a method to efficiently differentiate human iPSC into peptidergic nociceptors expressing CGRP and TRPV1, with functional maturity and drug response.

HTRA1 deficiency in COL4A1 mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel disease

This study identifies HTRA1 deficiency in COL4A1 mutant astrocytes as a mechanism underlying BBB dysfunction in cerebral small vessel disease.

GWAS of Extended Prescription Analgesic Use Identifies Novel Genetic Loci in Chronic Pain

This study uses prescription analgesic use data to identify 140 genetic associations with chronic pain, including 78 novel loci, and suggests new biological mechanisms.

Cerebral small vessel disease due to Col4a1 mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding.

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

Human iPSCs from aged donors retain their mitochondrial aging signature

This study shows that iPSCs from aged donors retain mitochondrial aging features like impaired bioenergetics and increased reactive oxygen species, suggesting they can model mitochondrial aging for drug screening.

Preservation of an Aging-Associated Mitochondrial Signature in Advanced Human Neuronal Models

This study compares aging-related mitochondrial characteristics in iPSC-derived neurons and direct conversion neurons, finding both retain age-associated phenotypes but differ in metabolic responses.

Single nuclear transcriptional signatures of dysfunctional brain vascular homeostasis in Alzheimer's disease

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

iPSC-Astrocyte morphology reflects patient clinical markers

This study shows iPSC-derived astrocytes from AD patients reflect key pathophysiological features, offering a new model for AD research and therapeutic screening.

Mathematical modelling of brain mTOR activity identifies selective vulnerability of cell types and signalling pathways

The paper uses mathematical modeling to analyze mTOR pathway activity in human brain cells, identifying cell-type-specific responses to ligands and changes in Alzheimer's Disease.

Neurons from individual early Alzheimer's disease patients reflect clinical vulnerability

The paper uses induced pluripotent stem cell-derived cortical neurons from early Alzheimer's patients to show that cellular vulnerability to amyloid-beta correlates with clinical vulnerability.

Cryptochrome Stabilization Ameliorates Chronic Pain

The paper identifies a peripheral molecular clock in sensory neurons that regulates diurnal pain behaviors and shows that stabilizing cryptochromes reduces pain sensitivity.

NOCICEPTRA: Gene and microRNA signatures and their trajectories characterizing human iPSC-derived nociceptor maturation

The paper characterizes human iPSC-derived nociceptor maturation using gene and microRNA expression trajectories and introduces a platform for querying these data.

rdrugtrajectory: An R Package for the Analysis of Drug Prescriptions in Electronic Health Care Records

The paper introduces an R package for analyzing drug prescriptions in electronic health care records to extract demographic and patient-level characteristics.

TASK-3 Two-Pore Potassium Channels drive neuronal excitability of the circadian clock and entrainment to challenging light environments

This study investigates the role of TASK-3 potassium channels in circadian clock neuronal excitability and behavioral adaptation to challenging light environments using a TASK-3 KO mouse model.