Caleb Webber

This paper describes a method to efficiently differentiate human iPSC into peptidergic nociceptors expressing CGRP and TRPV1, with functional maturity and drug response.

This study uses prescription analgesic use data to identify 140 genetic associations with chronic pain, including 78 novel loci, and suggests new biological mechanisms.

This study uses human iPSC-derived microglia with high polygenic AD risk to identify functional impairments in immune response, mitochondrial function, and amyloid-beta uptake.

The paper identifies transcriptional signatures in vascular cells from Alzheimer's disease brains, revealing dysregulated pathways linked to vascular dysfunction and immune activation.

This study shows that astrocytes derived from LMX1A+ progenitors lose lineage composition during differentiation unless progenitors are purified, using deep single-cell RNA sequencing.

This study identifies a small molecule, OXS-N1, that increases adult neurogenesis and improves memory in a mouse model of Alzheimer's disease through an in vitro phenotypic screen.

The paper presents a GWAS locus browser for Parkinson's disease that helps prioritize genes associated with risk variants from multiple GWAS studies.

The paper constructs a single-cell atlas of the Substantia nigra and identifies cell-specific gene expression patterns linked to Parkinson's disease and neuropsychiatric disorders.

This study identifies cell-type-specific expression of dystonia-associated genes and links them to shared genetic and biological mechanisms with psychiatric disorders.

This study identifies novel drug treatments for spinal muscular atrophy by integrating multi-omics data and drug perturbation profiles, showing harmine improves disease phenotypes in models.

This paper conducts a GWAS of mood instability in 363,705 UK Biobank participants, identifies 46 loci, and finds genetic correlations with psychiatric disorders and brain-specific gene expression.