The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells
Shadi Zahedi, Eliza Baird-Daniel, Kyle Brandon Williams, Rory L. Williams, Andrew Morin, Michelle Crespo, Emil Bratbak, Kendra Jones, Rajeev Vibhakar, Nicholas K. Foreman, David A. Largaespada, Jean M. Mulcahy Levy
This study shows that autophagy inhibition enhances MEK inhibitor effectiveness in NF1-mutated tumor cells, both in vitro and in a clinical trial.
bioRxiv · Nov 12, 2024 · PreprintCancer Biology