Rory L. Williams

This study identifies 23 compounds that selectively kill NF1-deficient Schwann cells and shows their efficacy in vivo, with synergy when combined with Selumetinib.

The paper introduces a method to efficiently integrate gene libraries onto yeast cytosolic plasmids using integrases, enhancing the versatility of OrthoRep for protein engineering.

This study shows that autophagy inhibition enhances MEK inhibitor effectiveness in NF1-mutated tumor cells, both in vitro and in a clinical trial.

This paper introduces a method to rapidly evolve genes in the lab, revealing new insights into enzyme adaptation that machine learning models cannot predict.

This paper introduces an improved AHEAD platform using a synthetic β-estradiol induction system to accelerate antibody evolution in yeast.

This study develops a differentiation circuit in E. coli to enhance the evolutionary stability of burdensome and toxic engineered functions through terminal differentiation.