Pathological meprin α expression associated with degradation of dermokine drives a psoriasis-like skin phenotype in a genetic mouse model
Vasco Köhling, Florian Peters, Inez Götting, Emil Fries, Niklas Beck, Fred Armbrust, Silje Beckinger, Cynthia Bülck, Vahap Canbay, Inken Harder, Marion Mengel, Malina Rüffer, Kira Bickenbach, Konstantinos Kalogeropoulos, Michaela Schweizer, , Sascha Rüffer
This study shows that increased meprin α expression in mice leads to a psoriasis-like skin phenotype through degradation of dermokine, promoting hyperproliferation and inflammation.
Journal of Investigative Dermatology · Feb 11, 2026Peer-reviewedMolecular Biology