Michaela Schweizer

This study identifies BMP's role in autophagosome-lysosome fusion by analyzing lysosomal proteomes and lipidomes in GNPTAB-deficient intestinal cells.

The paper characterizes the molecular architecture of somatic spines in the lateral septum across developmental stages using imaging techniques and cultured models.

The paper investigates the molecular mechanisms of early and late long-term potentiation (LTP) by manipulating CaMKII activity and shows that L-LTP can occur without CaMKII activation.

This study shows that increased meprin α expression in mice leads to a psoriasis-like skin phenotype through degradation of dermokine, promoting hyperproliferation and inflammation.

This study shows that extracellular vesicles from cortical neurons alter spontaneous activity in recipient neurons by increasing postsynaptic potential amplitude.

The paper induces spike-timing-dependent plasticity in hippocampal synapses using optogenetics and performs ultrastructural analysis with transmission electron microscopy.

This paper demonstrates that non-enzymatic methods can isolate brain-derived extracellular vesicles without compromising protein integrity, achieving high yield and purity.

This study identifies ADAM10's localization to presynaptic vesicles and shows its role in synaptic facilitation through interaction with synaptotagmin 7, independent of its proteolytic activity.

This study shows that astrocytic uptake of modified Aβ3(pE)-42 disrupts the endolysosomal system, leading to inflammation and synapse loss in Alzheimer's disease.

This study identifies cystatin C as a neuroprotective protein upregulated after stroke and shows that delivering it via brain-derived extracellular vesicles improves synaptic preservation in vitro and in vivo.

This study identifies KIF21B's role in regulating actin dynamics and AMPA receptor removal in dendritic spines during homeostatic synaptic downscaling.

This study shows that katanin, a microtubule-severing complex, is located at dendritic spines and regulates microtubule polymerization and synaptic plasticity through activity-dependent processes.

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.

The paper shows that unspecific expression in Cre-driver lines can lead to large functional effects, using SST-Cre mice to demonstrate excitatory current in non-target cells.

This study shows SIPA1L2 connects TrkB-containing amphisomes to dynein for retrograde trafficking and local signaling at presynaptic terminals, essential for BDNF-dependent plasticity.

The paper shows that Tao kinase regulates synaptic growth and connectivity in Drosophila nociceptive circuits to maintain specificity and function during larval development.