Author

Christoph Becker‐Pauly

Christian-Albrechts-Universität zu KielORCID 0000-0002-5100-9916Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Fred ArmbrustiD· 2 shared Andreu Matamoros‐AnglesiD· 1 shared Behnam MohammadiiD· 1 shared Berta PuigiD· 1 shared Carole CrozetiD· 1 shared Cathryn L. HaighiD· 1 shared Cécile Monzo· 1 shared Claus U. PietrzikiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Fred ArmbrustORCID

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Author profile →

3 papers

Recent·Most cited

Pathological meprin α expression associated with degradation of dermokine drives a psoriasis-like skin phenotype in a genetic mouse model

Vasco Köhling, Florian Peters, Inez Götting, Emil Fries, Niklas Beck, Fred Armbrust, Silje Beckinger, Cynthia Bülck, Vahap Canbay, Inken Harder, Marion Mengel, Malina Rüffer, Kira Bickenbach, Konstantinos Kalogeropoulos, Michaela Schweizer, , Sascha Rüffer

This study shows that increased meprin α expression in mice leads to a psoriasis-like skin phenotype through degradation of dermokine, promoting hyperproliferation and inflammation.

Journal of Investigative Dermatology · Feb 11, 2026Peer-reviewedMolecular Biology

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

Feizhi Song, Valerija Kovač, Behnam Mohammadi, Jessica Lisa Littau, Franka Scharfenberg, Andreu Matamoros‐Angles, Ilaria Vanni, Mohsin Shafiq, Leonor Orge, Giovanna Galliciotti, Salma Djakkani, Luise Linsenmeier, Maja Černilec, Katrina Pretnar Hartman, Sebastian Jung, , Hermann C. Altmeppen

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

Acta Neuropathologica · Jul 9, 2024Peer-reviewedNeuroscience

The Alzheimer’s disease associated bacterial protease RgpB from P. gingivalis activates the alternative β-secretase meprin β thereby increasing Aβ generation

Fred Armbrust, Cynthia Colmorgen, Claus U. Pietrzik, Christoph Becker‐Pauly

bioRxiv · Aug 28, 2019 · PreprintNeuroscience