Bradykinesia and postural instability in a model of prodromal Synucleinopathy with alpha-Synuclein aggregation in the gigantocellular nuclei.
Vasileios Theologidis, Sara Almeida Ferreira, Nanna Møller Jensen, Diana Gomes Moreira, Ole Andreas Ahlgreen, Mads W. Hansen, Emilie D. Rosenberg, Mette Richner, Islam Mustafa Galal Faress, Hjalte Gram, Poul Henning Jensen, Per Borghammer, Jens Randel Nyengaard, Marina Romero‐Ramos, Christian Bjerggaard Vægter, , Asad Jan
This study induces alpha-Synuclein aggregation in the gigantocellular nuclei of transgenic mice to model prodromal Parkinson's disease and observe motor symptom progression.
bioRxiv · Sep 5, 2024 · PreprintNeuroscience