Christian Bjerggaard Vægter

This study shows that DNA- and RNA-sensing immune pathways differently control genital HSV-2 infection and prevent neuroinvasion.

This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.

This study shows antidepressants interact with estrogen receptor alpha and its signaling pathways, suggesting a new mechanism for their therapeutic effects in mood disorders.

The paper measures soluble SORL1 (sSORL1) in CSF to assess functional impact of rare SORL1 variants, finding lower sSORL1 in carriers of pathogenic variants.

This study shows meteorin reduces nociceptive hypersensitivity by decreasing connexin-mediated coupling in satellite glial cells, with long-lasting therapeutic effects in pain models.

This study shows that chronic morphine exposure alters the transcriptomic and proteomic content of brain-derived extracellular vesicles from the prefrontal cortex, which can reprogram recipient neurons.

The paper characterizes satellite glial cell (SGC) subtypes in mouse and human dorsal root ganglia using single-cell RNA sequencing and spatial techniques, revealing distinct functional roles and spatial organization.

This paper introduces a hydrogel-electromagnetic biohybrid system that guides neural morphogenesis in both central and peripheral systems, improving neurite extension and functional recovery in human and rat models.

This study uses spatial transcriptomics to analyze aSyn pathology in mice, revealing metabolic and circadian disruptions at different stages of disease progression.

This study induces alpha-Synuclein aggregation in the gigantocellular nuclei of transgenic mice to model prodromal Parkinson's disease and observe motor symptom progression.

This paper develops AAV-delivered dimeric peptide inhibitors of PICK1 to alleviate neuropathic pain in mice, showing long-term relief without adverse effects.

This study compares the transcriptional response of satellite glial cells to nerve injury using single-cell RNA-seq and identifies a common signature involving cholesterol biosynthesis regulation.

The paper shows that α-synuclein pathology in Parkinson's disease activates the NRF2 anti-oxidant response, suggesting it could be a therapeutic target.