The Olfactory Epithelium: A Critical Gateway for Pathological Tau Propagation and a Target for Mitigating Tauopathy in the Central Nervous System
Marion Dourte, Esther Paître, Mongia Bouchoucha, Emilien Boyer, Sandra O. Tomé, Emilie Doeraene, Caroline Huart, Karelle Leroy, Dietmar Rudolf Thal, Anabelle Decottignies, Bernard Jimmy Hanseeuw, Núria Suelves, Pascal Kienlen‐Campard
This study shows that pathological tau spreads from the olfactory epithelium to brain regions in AD models and suggests targeting the olfactory epithelium to slow tauopathy progression.
Acta Neuropathologica · Jun 19, 2025Peer-reviewedNeuroscience