Bernard Jimmy Hanseeuw

Stage-dependent tau post-translational modifications map the spatiotemporal progression of Alzheimer's disease

This study maps stage-dependent tau post-translational modifications across Alzheimer's disease progression, revealing early phosphorylation and later ubiquitination events associated with tau aggregation.

Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer's Disease

The paper identifies gene associations with plasma pTau217 in preclinical Alzheimer's disease, showing modulation by APOEε4, Aβ-PET, and sex, with X-linked genes playing a role.

Alzheimer's disease and its co-pathologies: implications for hippocampal degeneration, cognitive decline, and the role of APOE ϵ4

This study examines the interactions between A{beta}, tau, LATE-NC, -synuclein, and APOE {varepsilon}4 in 480 post-mortem brains, finding that tau is the strongest predictor of neurodegeneration while LATE-NC primarily affects hippocampal neuron loss.

The Olfactory Epithelium: A Critical Gateway for Pathological Tau Propagation and a Target for Mitigating Tauopathy in the Central Nervous System

This study shows that pathological tau spreads from the olfactory epithelium to brain regions in AD models and suggests targeting the olfactory epithelium to slow tauopathy progression.

Erroneous compensation for long-latency feedback delays as origin of Essential Tremor

The paper investigates Essential Tremor by testing a hypothesis that impaired delay compensation in feedback control mechanisms causes the tremor, using experimental and computational methods.

Impairments of motor adaptation in Essential Tremor are linked to movement execution

This study investigates motor adaptation impairments in Essential Tremor patients and finds deficits in movement execution, while anticipatory components remain intact.

Mechanism of cellular production and in vivo seeding effects of hexameric β-amyloid assemblies

This study investigates the effects of hexameric β-amyloid assemblies on neuronal viability and amyloid deposition, finding no direct toxicity but an aggravating role in amyloid formation.

Unmasking selective path integration deficits in Alzheimer's disease risk carriers

The paper identifies selective path integration deficits in Alzheimer's disease risk carriers using virtual navigation tasks and fMRI, linking them to grid cell dysfunction in the entorhinal cortex.