Integrated Lineage Tracing in Hepatoblastoma Finds a Plasticity-Proliferation Axis Drives Adaptation
Emilia Chen, Christie English, Alejandro Allo Anido, Ayeh Sadat Sadr, Marc Miravet-Marti, Laura Zanatto, Andrea Michelle Castaneda Moreno, Siân Hamer, Emilie Inderise, Carolina Armengol, Pau Sancho‐Bru, Stefano Cairo, Alejandra Bruna
This study uses single-cell multiomics to trace clonal and phenotypic dynamics in hepatoblastoma after cisplatin treatment, identifying a plasticity-proliferation axis driven by BIRC5.
bioRxiv · Apr 16, 2025 · PreprintCancer Biology